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[43] The central role played by liver in the clearance and transformation of chemicals makes it susceptible to drug-induced injury

However, the significance of ROS as signaling molecule in controlling various biological activities associated with growth and development and other pathways that have a role in adaptation to various biotic stresses has also been studied

Charge fitting was performed using the RESP procedure with two fitting stages (hyperbolic constraint values: 0.0005/0.001), and intramolecular charge constraints on the N -methylamide fragment of glutamylmethylamide with a target value of zero were employed for charge derivation 71,72

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